Inflammatory Bowel Disease: Genetics, Barrier Function, and Immunologic Mechanisms, and Microbial Pathways

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Oktober 2006



Inflammatory bowel disease (IBD), which encompasses both Crohn's disease and ulcerative colitis, is a chronically relapsing intestinal disorder that is characterized by diarrhea and abdominal pain. The incidence of IBD is increasing worldwide.


Introduction: Current Limitations of IBD Treatment. Where Do We Go From Here?: S.R. Targan. Part I: Genetics of Inflammatory Bowel Disease -NOD/CARD Proteins: Diagnostic and Therapeutic Consequences?:. 1. Microbial Signaling Through NOD Proteins: D. Philpott. 2. NOD2/CARD Mutations in Crohn's Disease: J.P. Hugot. 3. Functional Relevance of NOD2 On Cellular Signalling in Crohn's Disease: G. Nunez. 4. Do Genetic Mutations Provide New Insights for Therapy?: J. Cho. Part II: Immunologic Abnormalities in IBD - What Can We Learn From Animal Models?:. 5. Role of TGFbeta in Mucosal Inflammation: W. Strober. 6. TNF/TNFR-Pathways in Chronic Inflammation: G. Kollias. 7. Lessons From Enteric Infections: L. Eckmann. 8. New Insights From Studies of Regulatory T Cell Populations: A. O'Garra. 9. the Commensal Microbial Flora: Relevance for Intestinal Inflammation: C.O. Elson. Part III: Immunologic Disturbances in Human IBD - Defining and Manipulating the Key Pathways:. 10. Chemokines and Cell Trafficking Within the Inflamed Mucosa -- Inhibition of Chemokine Receptors or Ligands as a Potential Approach for Treatment?: I.R. Williams. 11. Life and Death - the Role of Apoptosis: T. Kucharzik. 12. Cytokines - Who Are the Key Plays and the Role for Cytokine Treatment: R.S. Blumberg. 13. Novel Signal Transduction Pathways - Relevance for Future Therapies?: M.F. Neurath. 14. NF-Kappa-B Signaling -the Pros and Cons of Altering NF-kappaB as a Therapeutic Approach: M. Karin. 15. Intracellular Targets: a Role for Inhibition of MAP-Kinases in Therapy?: S.J. Deventer. 16. Leucocyte Adhesion Molecules - Are They Relevant as Target for IBD Treatment?: D.B. Binion. Part IV: Intestinal Epithelial Cells in IBD - An Active Barrier?:. 17. Tight Junction Function and the Modulation of Paracellular Permeability During IBD: a. Nusrat. 18. Epithelial Transport Under Inflammatory Conditions - Can It Be Regulated?: M.C. Berin. 19. Imbalance of Epithelial Electrolyte Homeostasis - Role in the Pathophysiology of IBD: U. Seidler. 20. Neutrophil Transepithelial Migration and Epithelial Barrier Function in IBD - Potential Targets for Inhibiting Neutrophil Trafficking: C.A. Parkos. Part V: GALT - Relevant for Regulation of Inflammation?:. 21. Collaboration of Epithelial Cells With Organized Lymphoid Tissue: M.J. Kraehenbuhl. 22. Role of Lymphotoxins in the Development of PP and MLN - Relevance to Intestinal Inflammation and Treatment: T.W. Spahn. 23. Trafficking and Function of Mucosal Dendritic Cells: A. Iwasaki. 24. Intraepithelial T-Cells - Implication for Intestinal Inflammation: M. Kronenberg. Part VI: Relevance of Microbial Factors - Additive Or Causative for IBD?:. 25. Microbial - Epithelial Cell Crosstalk During Inflammation: The Host Response: M. Kagnoff. 26. Role of Toll-Like Receptors in Orchestrating the Innate Immune Response - Potential Targets for Treatment?: D. Podolsky. 27. Host-Bacterial Interactions in the Gut: Signalling by Commensal Flora: J. Gordon. 28. Immunostimulatory DNA- Potential Therapeutics for Treatment of Enteric Inflammatory Disease?: E. Raz. 29. Probiotics - Their Role in Controlling Intestinal Inflammation?: J.F. Colombel. 30. Inflammatory Bowel Disease - Pandora's Box, Present and Future: J. Scholmerich. Index of Contributors
EAN: 9781573315685
ISBN: 1573315680
Untertitel: 'Annals of the New York Academy'. Sprache: Englisch.
Erscheinungsdatum: Oktober 2006
Seitenanzahl: 412 Seiten
Format: kartoniert
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