Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems

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September 2012



The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to phenomenological models of nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 4 is devoted to major sets of intracellular mediators that transmit signals upon stimulation of cell-surface receptors.  Activation of signaling effectors triggers the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Complex stages of cell signaling can be studied using proper mathematical models, once the role of each component is carefully handled.  Volume 4 also reviews various categories of cytosolic and/or nuclear mediators and illustrates some major signal transduction pathways, such as NFkappaB axis, oxygen sensing, and mechanotransduction.


1. Introduction2. Signaling Lipids3. Preamble to Cytoplasmic Protein Kinases4. Cytoplasmic Protein Tyrosine Kinases5. Cytoplasmic Protein Serine/Threonine Kinases6. Dual-Specificity Protein Kinases7. Mitogen-Activated Protein Kinase Module8. Dual-Specificity Protein Kinases9. Guanosine Triphosphatases and Their Regulators10. Other Major Types of Signaling Mediators11. Signaling Pathways12. ConclusionReferencesList of Currently Used Prefixes and SuffixesList of AliasesComplementary Lists of NotationsIndex


EAN: 9781461443704
Untertitel: 2013. Auflage. 31 schwarz-weiße Abbildungen, 339 schwarz-weiße Tabellen, Bibliographie. eBook. Sprache: Englisch. Dateigröße in MByte: 10.
Verlag: Springer New York
Erscheinungsdatum: September 2012
Seitenanzahl: xv1064
Format: pdf eBook
Kopierschutz: Adobe DRM
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