Laboratory Animal Medicine

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Oktober 2013



Laboratory Animal Medicine is a compilation of papers that deals with the diseases and biology of major species of animals used in medical research. The book discusses animal medicine, experimental methods and techniques, design and management of animal facilities, and legislation on laboratory animals. Several papers discuss the biology and diseases of mice, hamsters, guinea pigs, and rabbits. Another paper addresses the dog and cat as laboratory animals, including sourcing of these animals, housing, feeding, and their nutritional needs, as well as breeding and colony management. The book also describes ungulates as laboratory animals, including topics on sourcing, husbandry, preventive medical treatments, and housing facilities. One paper addresses primates as test animals, covering the biology and diseases of old world primates, Cebidae, and ferrets. Some papers pertain to the treatment, diseases, and needed facilities for birds, amphibians, and fish. Other papers then deal with techniques of experimentation, anesthesia, euthanasia, and some factors (spontaneous diseases) that complicate animal research. The text can prove helpful for scientists, clinical assistants, and researchers whose work involves laboratory animals.


1;Front Cover;1 2;Laboratory Animal Medicine;4 3;Copyright Page;5 4;Table of Contents;6 5;List of Contributors;10 6;Preface;12 7;List of Reviewers for Chapters in This Volume;14 8;Chapter 1. Laboratory Animal Medicine: Historical Perspectives;18 8.1;I. Introduction;18 8.2;II. Origins of Animal Experimentation;19 8.3;III. Early Veterinarians in Laboratory Animal Science and Medicine;21 8.4;IV. The Organizations of Laboratory Animal Science;24 8.5;V. Education and Training in Laboratory Animal Medicine;31 8.6;VI. Impact of Laws, Regulations, and Guidelines on Laboratory Animal Medicine;32 8.7;VII. Regulation of Animal Research in the United Kingdom and Canada;32 8.8;VIII. Commercial Rodent Breeding;33 8.9;IX. Conclusion;33 8.10;References;33 9;Chapter 2. Laws, Regulations, and Policies Affecting the Use of Laboratory Animals;36 9.1;I. Introduction;36 9.2;II. Animal Welfare;37 9.3;III. Collection, Importation, Exportation, and Shipment of Animals;43 9.4;IV. Hazardous Substances;45 9.5;V. Good Laboratory Practices;46 9.6;References;46 10;Chapter 3. Biology and Diseases of Mice;48 10.1;I.Introduction;48 10.2;II. Biology;53 10.3;III. Diseases;61 10.4;References;105 11;Chapter 4. Biology and Diseases of Rats;108 11.1;I. Introduction;108 11.2;II. Biology;110 11.3;III. Diseases;116 11.4;References;137 12;Chapter 5. Biology and Diseases of Hamsters;140 12.1;Syrian Hamster;141 12.2;Chinese Hamster;157 12.3;European Hamster;160 12.4;Armenian Hamster;161 12.5;References;162 13;Chapter 6. Biology and Diseases of Guinea Pigs;166 13.1;I. Introduction;166 13.2;II. Biology;167 13.3;III. Diseases;175 13.4;References;194 14;Chapter 7. Biology and Diseases of Other Rodents;200 14.1;I. Introduction;200 14.2;II. Biology;207 14.3;III. Diseases;211 14.4;References;222 15;Chapter 8. Biology and Diseases of Rabbits;224 15.1;I. Introduction;224 15.2;II. Biology;226 15.3;III. Diseases;234 15.4;References;254 16;Chapter 9. Dogs and Cats as Laboratory Animals;258 16.1;I. Introduction;258 16.2;II.
Types and Sources of Dogs and Cats;259 16.3;III. Housing;260 16.4;IV. Conditioning;261 16.5;V. Canine and Feline Breeding Colony Management;267 16.6;VI. Nutrition and Feeding;274 16.7;VII. Diseases;275 16.8;VIII. Selected Normative Data;284 16.9;References;285 17;Chapter 10. Ungulates as Laboratory Animals;290 17.1;I. Introduction;291 17.2;II. Taxonomy;291 17.3;III. General Comments and Examples of Use in Research;291 17.4;IV. Availability, Sources, and Acquisition;292 17.5;V. Evaluation of Incoming Animals;293 17.6;VI. Routine Health Maintenance;296 17.7;VII. Synchronization of Ovulation;296 17.8;VIII. Facilities;296 17.9;IX. Appendix;299 17.10;References;311 18;Chapter 11. Primates;314 18.1;Introduction;315 18.1.1;References;318 18.2;Part A. Biology and Diseases of Old World Primates;318 18.2.1;References;336 18.3;Part B. Biology and Diseases of Cebidae;338 18.3.1;References;367 18.4;Part C. Biology and Diseases of Callitrichidae;370 18.4.1;References;396 19;Chapter 12. Biology and Diseases of Ferrets;402 19.1;I. Introduction;403 19.2;II. Biology;403 19.3;III. Routine Veterinary Medical Care;406 19.4;IV. Infectious Diseases;406 19.5;V. Nutritional and Metabolic Diseases;411 19.6;VI. Neoplastic Diseases;413 19.7;References;413 20;Chapter 13. Biology and Diseases of Birds;416 20.1;I. Introduction;417 20.2;II. Biology;419 20.3;III. Diseases Caused by Bacteria;420 20.4;IV. Diseases Caused by Viruses;428 20.5;V. Diseases Caused by Parasites;433 20.6;VI. Diseases Caused by Fungi/Yeasts;437 20.7;VII. Diseases Resulting in Neoplastic Changes;438 20.8;VIII. Diseases Caused by Nutritional Deficiencies;439 20.9;Selected References;442 21;Chapter 14. Biology and Diseases of Amphibians;444 21.1;I. Introduction;444 21.2;II. Biology;444 21.3;III. Diseases;451 21.4;References;462 22;Chapter 15. Biology and Diseases of Reptiles;466 22.1;I. Introduction;466 22.2;II. Biology;469 22.3;III. Diseases;477 22.4;References;493 23;Chapter 16. Biology and Diseases of Fish;496 23.1;I. Intro
duction;496 23.2;II. Biology;498 23.3;III. Diseases;506 23.4;References;522 24;Chapter 17. Design and Management of Animal Facilities;524 24.1;I. Introduction;524 24.2;II. Facilities Design and Equipment;524 24.3;III. Management;540 24.4;IV. Conclusion;543 24.5;References;543 25;Chapter 18. Preanesthesia, Anesthesia, Analgesia, and Euthanasia;546 25.1;I. Introduction;547 25.2;II. Preanesthesia, Anesthesia, and Analgesia;547 25.3;III. Euthanasia;573 25.4;References;580 26;Chapter 19. Techniques of Experimentation;582 26.1;I. Introduction;583 26.2;II. Identification Methods;583 26.3;III. Blood Collection and Intravenous Injection;584 26.4;IV. Vascular Cannulation;588 26.5;V. Intraperitoneal Injection;588 26.6;VI. Subcutaneous and Intramuscular Injection;589 26.7;VII. Oral Administration of Substances;589 26.8;VIII. Digestive System;589 26.9;IX. Urinary Techniques;592 26.10;X. Respiratory System Techniques;594 26.11;XI. Reproductive System ;597 26.12;XII. Cardiovascular Techniques;600 26.13;XIII. Endocrine System Techniques;601 26.14;XIV. Orthopedic Procedures for Laboratory Animals;603 26.15;XV. Neurosurgical Techniques;603 26.16;XVI. Tumor Transplantation;606 26.17;References;607 27;Chapter 20. Control of Biohazards Associated with the Use of Experimental Animals;614 27.1;I. Introduction;614 27.2;II. The Infectious Process;615 27.3;III. Risk Assessment;616 27.4;IV. Biosafety Practices and Procedures;616 27.5;V. Summation;621 27.6;References;621 28;Chapter 21. Genetic Monitoring;622 28.1;I. Introduction;622 28.2;II. Sources of Genetic Impurity of Inbred Strains;623 28.3;III. Evidence of Genetic Contamination;624 28.4;IV. Methods of Genetic Monitoring;625 28.5;V. Summary;630 28.6;References;630 29;Chapter 22. Selected Zoonoses and Other Health Hazards;632 29.1;I. Introduction;633 29.2;II. Viral Diseases;633 29.3;III. Rickettsial and Chlamydial Diseases;640 29.4;IV. Bacterial Diseases;643 29.5;V. Mycoses;650 29.6;VI. Protozoan Diseases;652 29.7;VII. Helminth Infections;
655 29.8;VIII. Arthropod Infestations;655 29.9;IX. Bites and Scratches;659 29.10;X. Allergic Sensitivities;661 29.11;XI. Conclusions;662 29.12;References;662 30;Chapter 23. Factors That Complicate Animal Research;668 30.1;I. Introduction;668 30.2;II. Physical Factors;669 30.3;III. Chemical Factors;671 30.4;IV. Microbial Factors;676 30.5;References;679 31;Chapter 24. Animal Models in Biomedicai Research;686 31.1;I. Introduction;686 31.2;II. History;687 31.3;III. Symposia;689 31.4;IV. Publications;690 31.5;V. Selection of Animals;690 31.6;VI. Selected Animal Models;691 31.7;References;707 31.8;Additional Books, Proceedings, and Bulletins;713 32;Chapter 25. Developing Research in Laboratory Animal/Comparative Medicine;716 32.1;I. Introduction;716 32.2;II. The Research Process;717 32.3;III. Training for Research in Laboratory Animal/Comparative Medicine;720 32.4;IV. Development of Research Resources;721 32.5;V. Support for Research;724 32.6;References;725 33;Chapter 26. Rodent and Lagomorph Health SurveillanceQuality Assurance;728 33.1;I. Introduction;728 33.2;II. Design of Quality Assurance Programs;729 33.3;III. Quarantine;738 33.4;IV. Conclusions;740 33.5;References;741 34;Index;744

EAN: 9781483269160
Untertitel: 200:Adobe eBook. Sprache: Englisch.
Verlag: Elsevier Science
Erscheinungsdatum: Oktober 2013
Format: pdf eBook
Kopierschutz: Adobe DRM
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