Atlas of Human Tumor Cell Lines

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Oktober 2013



Human tumor cells in culture are valuable for studying cancer causes and properties. This convenient reference provides useful information for cancer researchers on commonly used, established tumor cell lines of the major human organ systems.

Atlas of Human Tumor Cell Lines includes data about morphological, metabolic, genetic, and growth characteristics of human tumor cells, with morphological characteristics presented in more than 250 photomicrographs. It also contains information for establishing and maintaining human tumor cell lines in culture, and each chapter covers future perspectives.

  • Covers well-characterized tumor cell lines from the major human organ systems
  • Presents over 250 photomicrographs, both phase-contrast and electron micrographs
  • Includes a list of key references for each chapter
  • Written by world-renowned experts


1;Front Cover;1 2;Atlas of Human Tumor Cell Lines;4 3;Copyright Page;5 4;Table of Contents;6 5;Preface;12 6;Chapter 1. Quality Control and Characterization of Cell Lines;14 6.1;I. Introduction;14 6.2;II. Seed Stock Concept;15 6.3;III. Microbial Contamination;16 6.4;IV. Cellular Cross-Contamination;21 6.5;V. Origin and Function;26 6.6;VI. Conclusions;27 6.7;References;27 7;Chapter 2. Human Glioma Cell Lines;30 7.1;I. Introduction;30 7.2;II. Cell Lines Derived from Glioblastoma Multiforme and Anaplastic Astrocytoma;31 7.3;III. Cell Lines Derived from Oligodendroglioma;44 7.4;IV. Cell Lines Derived from Primitive Neuroectodermal Tumor/Medulloblastoma;45 7.5;V. Concluding Remarks;46 7.6;References;47 8;Chapter 3. Tumor Cell Lines of the Peripheral Nervous System;56 8.1;I. Neuroblastoma;58 8.2;II. Peripheral Neuroepithelioma;74 8.3;Acknowledgments;83 8.4;References;83 9;Chapter 4. Head and Neck Tumor Cell Lines;92 9.1;I. Introduction;92 9.2;II. Methods of Establishment and Maintenance;94 9.3;III. Morphology;109 9.4;IV. Other Characteristics;126 9.5;V. Discussion;128 9.6;VI. Future Prospects;130 9.7;References;130 10;Chapter 5. Cell Culture of Lung Cancers;134 10.1;I. Cellular Origins of Lung Cancers;134 10.2;II. Major Forms of Lung Cancer;136 10.3;III. Defined Media for the Culture of Lung Tumors;137 10.4;IV. Establishment of Small-Cell Lung Carcinoma Cell Lines;138 10.5;V. Other Neuroendocrine Tumors;147 10.6;VI. Cell Lines Derived from Non-Small-Cell Lung Carcinoma;149 10.7;VII. Mesotheliomas;159 10.8;VIII. Conclusions;159 10.9;References;159 11;Chapter 6. Cell Lines from Human Breast;174 11.1;I. Introduction;174 11.2;II. Methods of Establishment and Maintenance;175 11.3;III. Morphology;175 11.4;IV. Discussion;193 11.5;V. Future Prospects;194 11.6;Acknowledgment;194 11.7;References;194 12;Chapter 7. Hepatocellular Carcinomas;198 12.1;I. Introduction;198 12.2;II. Undifferentiated Hepatocellular Carcinoma Cell Line HLE;199 12.3;III. Differentiated Hepatocellular Carcinom
a Cell Lines;202 12.4;IV. Differentiated Hepatoblastoma Cell Lines;212 12.5;V. Conclusions;218 12.6;References;218 13;Chapter 8. Hematopoietic Cell Lines;226 13.1;I. Introduction;226 13.2;II. Culture of Hematopoietic Cells;227 13.3;III. LeukemiaLymphoma Cell Lines;230 13.4;IV. Characterization of Leukemia Cell Lines;232 13.5;V. Growth Factor-Dependent Leukemia Cell Lines;255 13.6;VI. Hodgkin's Disease-Derived Cell Lines;256 13.7;VII. Future Prospects;257 13.8;VIII. Lists of Leukemia Cell Lines;262 13.9;References;262 14;Chapter 9. Human Sarcoma Cells in Culture;264 14.1;I. Introduction;264 14.2;II. Methods of Establishment and Maintenance;265 14.3;III. Specific Cell Line Characteristics;268 14.4;References;278 15;Chapter 10. Cell Lines from Esophageal Tumors;282 15.1;I. Introduction;282 15.2;II. Methods of Establishment and Maintenance;283 15.3;III. Morphology;286 15.4;IV. Other Characteristics;290 15.5;V. Discussion;292 15.6;VI. Future Prospects;295 15.7;Acknowledgment;295 15.8;References;295 16;Chapter 11. Gastric Tumor Cell Lines;300 16.1;I. Introduction;300 16.2;II. Methods of Establishment and Maintenance;301 16.3;III. Morphology;305 16.4;IV. Other Characteristics;322 16.5;V. Future Prospectives;325 16.6;References;327 17;Chapter 12. Colorectal Cancer Cell Lines;330 17.1;I. Introduction;330 17.2;II. Establishment of Cell Lines;333 17.3;III. Culture Characteristics;337 17.4;IV. Morphological Characteristics;338 17.5;V. Other Characteristics;347 17.6;References;351 18;Chapter 13. Cell Lines from Urinary Bladder Tumors;354 18.1;I. Background;355 18.2;II. Patient History and History of Original Tumor;355 18.3;III. Histological Examination of the Original Tumors and Developed Cell Cultures;360 18.4;IV. Establishment and Maintenance of Bladder Cancer Lines;366 18.5;V. Mycoplasma Testing;366 18.6;VI. Cryopreservation of Cell Lines;366 18.7;VII. Characterization of Lines;367 18.8;VIII. Summary;372 18.9;Acknowledgments;373 18.10;References;373 19;Chapter 14. The Female
Reproductive System: Cell Lines from Tumors of the Human Ovary and Uterus;376 19.1;I. Introduction;376 19.2;II. Methods of Establishment and Maintenance of Cell Lines;377 19.3;III. Morphological Aspects;380 19.4;IV. Growth and Other Characteristics;394 19.5;V. Future Prospects;401 19.6;Acknowledgments;401 19.7;References;401 20;Chapter 15. The Male Reproductive System: Prostatic Cell Lines;404 20.1;I. Introduction;404 20.2;II. Methods of Establishment and Maintenance;405 20.3;III. Morphology;408 20.4;IV. Other Characteristics;413 20.5;V. Discussion and Future Prospects;422 20.6;References;424 21;Chapter 16. Melanocyte and Melanoma Cell Lines;430 21.1;I. Introduction;430 21.2;II. Establishment and Maintenance;431 21.3;III. Morphology of Cultured Melanocytes and Melanoma Cells;433 21.4;IV. Growth Characteristics;433 21.5;V. Growth Factor Production by Melanoma Cells;436 21.6;VI. Chromosomal Abnormalities in Melanoma Cells;437 21.7;VII. Antigen Expression by Melanocytic Cells;438 21.8;VIII. Invasion and Metastasis of Melanoma Cells;439 21.9;IX. Conclusions;441 21.10;X. Origin of Cell Lines;442 21.11;Acknowledgement;443 21.12;References;443 22;Chapter 17. Exocrine Pancreatic Tumor Cell Lines;446 22.1;I. Introduction;446 22.2;II. Methods of Establishment and Maintenance;449 22.3;III. Morphology;449 22.4;IV. Other Characteristics;453 22.5;V. Induction of Differentiation;453 22.6;VI. Discussion;456 22.7;VII. Future Prospects;457 22.8;References;457 23;Chapter 18. Cell Lines from Human Germ-Cell Tumors;460 23.1;I. Introduction;460 23.2;II. Establishment and Maintenance of Cell Lines;462 23.3;III. Morphology;468 23.4;IV. Other Characteristics;475 23.5;V. Discussion and Future Prospects;480 23.6;VI. Reported Cell Lines Derived from Human Germ-Cell Tumors;483 23.7;Acknowledgments;486 23.8;References;487 24;Index;494

EAN: 9781483288628
Untertitel: 200:Adobe eBook. Sprache: Englisch. Dateigröße in MByte: 163.
Verlag: Elsevier Science
Erscheinungsdatum: Oktober 2013
Seitenanzahl: 486 Seiten
Format: pdf eBook
Kopierschutz: Adobe DRM
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