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Introduction to Peptides and Proteins

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November 2009

Beschreibung

Beschreibung

Authored by key players in the field, this volume offers a relevant presentation of peptide and protein chemistry. It provides key insight into the fast-developing field of proteomics, including structural and functional aspects, biochip development, and clinical potential. It include schapters on bioinformatics and proteomics and present the latest information on concerns over protein degradation and the post-translational modifications of proteins and peptides. The book also includes a section on protein-coupled diseases that presents increasing evidence of the pathological impact of protein misfolding in relation to various neurodegenerative diseases, as well as a section on the role of proteins in cancer.


Inhaltsverzeichnis

Preface

Further Reading

Biography



Introduction to Part 1; Matjaz Zorko

From Building Block to 3-D Structure

Amino Acids; Matjaz Zorko

Noncovalent Interactions; Matjaz Zorko

Structural Organization of Proteins; Matjaz Zorko



Protein Biosynthesis and Posttranslational Modifications

The Biosynthesis of Proteins; Matjaz Zorko

Posttranslational Modifications; Matjaz Zorko



Folding of Proteins

Protein Folding; Matjaz Zorko

Intracellular Sorting of Proteins; Gunnar von Heijne



Protein Degradation

Protein Turnover; Matjaz Zorko



Introduction to Part II; Astrid Graslund

Purification and Characterization of Proteins; Matjaz Zorko

Crystallography and X-Ray Diffraction Astrid Graslund

Optical Spectroscopy; Astrid Graslund

Nuclear Magnetic Resonance (NMR); Astrid Graslund

Methods to Follow Protein Folding; Astrid Graslund

Mass Spectrometry; Astrid Graslund

Chemical Synthesis of Peptides and Proteins; Ulo Langel



Introduction to Part III; Tiit Land

Protein Engineering and Gene Silencing; Ulo Langel

Protein-Ligand Interactions; Ulo Langel

Sequence Analysis and Function Prediction; Tiit Land

Protein Structure Prediction; Tiit Land

Proteomics; Sherry Niessen and Benjamin F. Cravatt



Introduction to Part IV; Ulo Langel

Enzymes; Matjaz Zorko

Nucleic Acid-Binding Proteins; Ulo Langel

Cell Surface Receptors and Signaling; Ulo Langel

Membrane Proteins; Gunnar von Heijne

Antibodies; Ulo Langel

Fibrous Proteins; Ulo Langel

Selected Classes of Bioactive Peptides; Ulo Langel

Introduction to Part V; Ulo Langel and Astrid Graslund

Misfolding-Based Diseases; Astrid Graslund

Miscleavage-Based Diseases; Astrid Graslund

Missequence-Based Diseases; Astrid Graslund

Peptides and Proteins as Drugs; Ulo Langel

Portrait

Stockholm University, Sweden The Scripps Research Institute, La Jolla, California, USA University of Stockholm, Sweden University of Ljubljana, Slovenia
EAN: 9781420064124
ISBN: 1420064126
Untertitel: Sprache: Englisch.
Verlag: CRC PR INC
Erscheinungsdatum: November 2009
Seitenanzahl: 424 Seiten
Format: gebunden
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