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Stability of Protein Pharmaceuticals: Part B: In Vivo Pathways of Degradation and Strategies for Protein Stabilization

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November 1992

Beschreibung

Beschreibung

Part B explores protein degradation occuring in vivo during protein synthesis in cells, examines the isolation and purification of proteins, details protein use in organisms, and reviews techniques to enhance protein stability.

Inhaltsverzeichnis

Improper Glycosylation and the Cellular Editing of Nascent Proteins; D.A. Cumming. Protein Aggregation In Vivo; R. Wetzel. Pathways of Intracellular Protein Degradation in Eukaryotic Cells; T.S. Olson, et al. Effects of Aging on Proteins; R.W. Gracy. Engineering Dramatic Increases in the Stability of Subtilisin; P.N. Bryan. Increased Stability of Mutant Forms of Yeast Cytochrome c; D.R. Hickey, et al. Introduction to Formulation of Protein Pharmaceuticals; M.A. Hanson, S.K.E. Rouan. PEG Modified Proteins; G.E. Francis, et al. Stabilization of Protein Structure by Solvent Additives; S.N. Timasheff. Heat-Shock Proteins and their Potential Uses for Pharmaceutical Protein Production in Microorganisms; J.M. McCoy. Index.

Pressestimmen

`Offers the most comprehensive treatment to date of the various degradation pathways of pharmaceutical proteins....The two-volume set is an essential reference for pharmaceutical scientists.'
BioPharm
EAN: 9780306441530
ISBN: 0306441535
Untertitel: 1992. Auflage. Sprache: Englisch.
Verlag: SPRINGER VERLAG GMBH
Erscheinungsdatum: November 1992
Seitenanzahl: 328 Seiten
Format: gebunden
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