Synthesis of Essential Drugs:

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April 2006



This book represents an effort to express a long overdue need of compiling information which has been accumulated over the course of more than 30 years of our work in the area of the synthesis of medicinal drugs. Our effort fills obvious gaps that exist in the literature of drug synthesis. The synthesis of various groups of drugs are presented in an order similar to that traditionally presented in a pharmacology curriculum. This was done with a very specific goal in mind to harmonize the chemical aspects with the pharmacology curriculum in a manner useful to chemists. Practically every chapter begins with an accepted brief definition and description of a particular group of drugs, proposes their classification, and briefly explains the present model of their action. This is followed by a detailed description of methods for their synthesis. Of the thousands of drugs existing on the pharmaceutical market, we mainly discuss generic drugs that are included in the WHOs "Essential List of Drugs." For practically all of the 700+ drugs described in the book, references (around 2350) to the methods of their synthesis are given along with the most widespread synonyms. This book will provide the kind of information that will be of interest to those who work, or plan to begin work in the captivating areas of biologically active compounds and the synthesis of medicinal drugs. * Provides a brief description of methods of synthesis, activity and implementation of all drug types* Includes synonyms* Includes over 2300 references


1. General Anesthetics 2. Local Anesthetics 3. Analgesics 4. Hypnotics and Sedatives 5. Anxiolitics (Tranquilizers) 6. Antipsycotics (Neuroleptics) 7. Antidepressants 8. Central Nervous System Stimulants 9. Antiepileptics 10. Anti-Parkinson Drugs 11. Adrenegic (Sympatomimetic) Drugs 12. Adrenoblocking Drugs 13. Cholinomimetics 14. Anticholinergic Drugs 15. Muscle Relaxants 16. Antihistamine Drugs 17. Cardiac Glycosides and Other Inotropes 18. Drugs for Tachyarrhytmias 19. Antianginal Drugs 20. Agents Used in Hyperlipoproteinemia 21. Diuretics 22. Antihypertensive Drugs 23. Drugs for Treating of Pulmonary Diseases 24. Anticoagulants, Antiagregants, Trombolytics and Hemostatics 25. Thyroid and Parathyroid Drugs 26. Insulin and Synthetic Hypoglycemic Agents 27. Corticosteroids 28. Female Sex Hormones 29 Male Sex Hormones and Anabolics 30. Antineoplastic Agents 31. Immunopharmacologic Drugs 32. Antibiotics 33. Antimicrobials 34. Antimicobacterials 35. Antifungal Drugs 36. Antiviral Drugs 37. Antiprotozoal Drugs 38. Antihelmint Drugs


* Provides a brief description of methods of synthesis, activity and implementation of all drug types * Includes synonyms * Includes over 2300 references
EAN: 9780444521668
ISBN: 0444521666
Untertitel: Sprache: Englisch.
Erscheinungsdatum: April 2006
Seitenanzahl: 617 Seiten
Format: gebunden
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