NO modulation and potential antiarthritic effect of rolipram

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Oktober 2015



Rolipram is a phosphodiesterase-4 (PDE 4) inhibitor. It is being researched as a possible alternative to current antidepressants (Washtel, 1983; Bobon et al., 1988). Recent studies show that rolipram may have antipsychotic effects (Maxwell et al.,2004; Kanes et al., 2006).There is a conflicting data about the role of nitric oxide (NO) in arthritic diseases. In the present work, we examined whether the suppression of NO production by L- NG - monomethyl arginine (L-NMMA), a non-selective NOS inhibitor or addition of exogenous NO by administration of sodium nitroprusside (SNP) can modify the effects of rolipram in adjuvant arthritic rats.


Dr.Romany H Thabet, Assistant prof.of pharmacology, faculty of medicine, Northern Borders University. My recent publications is '' Genetic variants in 6-mercaptopurine pathway as potential factors of hematological toxicity in acute lymphoblastic leukemia patients''.Pharmacogenomics 2015 Aug 3:1-15.
EAN: 9783659791963
ISBN: 3659791962
Untertitel: Paperback. Sprache: Englisch.
Verlag: LAP Lambert Academic Publishing
Erscheinungsdatum: Oktober 2015
Seitenanzahl: 132 Seiten
Format: kartoniert
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