Quetiapine vs Haloperidol in Schizophrenia

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Dezember 2011



Quetiapine, a dibenzothiazepine derivative, is a novel antipsychotic with demonstrated efficacy in acute schizophrenia. It is closest to Clozapine in its pharmacological profile but is free of the life threatening side effects like agranulocytosis. It may well replace Clozapine in the treatment of refractory schizophrenia and in bringing some miraculous improvements (awakening) in chronic schizophrenia. In addition to improvement in positive and negative symptoms it has also exhibited a beneficial effect for treatment of affective and cognitive dysfunctions in patients of schizophrenia. The salient feature of quetiapine is tolerability in terms of EPS, absence of any effect on prolactin levels and minimal effect on weight, that differentiate it from the other available antipsychotic drugs. Preliminary studies indicate that there is a high level of patient acceptability and satisfaction with quetiapine. Overall, quetiapine is as effective as risperidone or olanzapine for the treatment of psychotic symptoms, and is more effective for the treatment of depressive symptoms. It has an excellent risk/benefit profile and is a suitable first-line option for the treatment of schizophrenia.


"Things won't ever be perfect, but they can almost always improve"Dr. Ravi PaulMBBS,MDConsultant PsychiatristHead Department of Psychiatry, University of ZambiaInvolved in implementation and running of the Masters Programme in Psychiatry, training Mental Health Professionals as well as in developing Child and Adolescent Psychiatric services
EAN: 9783846591048
ISBN: 3846591041
Untertitel: A randomized control trial to compare safety, efficacy and tolerability of Quetiapine vs Haloperidol in Schizophrenia. Paperback. Sprache: Englisch.
Verlag: LAP Lambert Academic Publishing
Erscheinungsdatum: Dezember 2011
Seitenanzahl: 108 Seiten
Format: kartoniert
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