HUDU

The Rat as Animal Model in Breast Cancer Research


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Januar 1984

Beschreibung

Inhaltsverzeichnis

1 Introduction.
- 1.1 Breast Cancer - An Overview.
- 1.2 Purpose of the Study.- 2 Animals and Experimental Methodology.
- 2.1 Rationale for Choice of Rat Strains.
- 2.2 Origin of the Rats.
- 2.3 Selected Biological Characteristics of the Rats.
- 2.3.1 Growth Curves.
- 2.3.2 Breeding Data.
- 2.3.3 Selected Immunogenetic Data.
- 2.4 Husbandry Conditions.
- 2.5 Irradiation.
- 2.6 Hormone Administration.
- 2.7 Castration.
- 2.8 Clinical Examination.
- 2.9 Necropsy Procedures.
- 2.10 Statistical Evaluation.- 3 Effects of Irradiation and Hormone Administration on Mammary Tumor Incidence.
- 3.1 Introduction.
- 3.2 Experimental Data.
- 3.3 Crude Mammary Tumor Incidence Results.
- 3.4 Dose-Effect Relationships.
- 3.5 Conclusions.- 4 Normal Anatomy and Pathology of the Rat Mammary Gland.
- 4.1 The Normal Mammary Gland.
- 4.1.1 Anatomic Considerations.
- 4.1.2 Histological Structure.
- 4.1.3 Development.
- 4.2 Pathological Changes - A Classification.
- 4.3 Nonneoplastic Lesions.
- 4.4 Neoplastic Lesions.
- 4.4.1 Benign Mammary Tumors.
- 4.4.2 Malignant Mammary Tumors.
- 4.5 Histogenesis and Interrelationships of Certain Mammary Gland Lesions.
- 4.6 Discussion.
- 4.6.1 Histological Types of Rat Mammary Neoplasms.
- 4.6.2 "Malignancy" of the Rat Mammary Carcinoma.- 5 Correlation of Mammary Tumor Histology with Experimental Procedures.
- 5.1 Introduction.
- 5.2 Tumor Types and Treatment Relationships.
- 5.3 Topographical Distribution of Mammary Tumors.
- 5.4 Discussion.- 6 Lesions of the Pituitary Gland and Liver.
- 6.1 Introduction.
- 6.2 Pituitary Gland.
- 6.2.1 Background Remarks.
- 6.2.2 Morphological Aspects.
- 6.2.3 Effect of Irradiation and/or Estrogen Administration on Pituitary Tumor Incidence.
- 6.2.4 Interrelationships Between Pituitary Tumors, Plasma Prolactin Levels and Mammary Tumors.
- 6.2.5 Discussion.
- 6.3 Liver.
- 6.3.1 Background Remarks.
- 6.3.2 Morphological Aspects.
- 6.3.3 Results.
- 6.3.4 Discussion.- 7 General Discussion, Including a Brief Review of Animal Models in Breast Cancer Research.
- 7.1 Synthesis.
- 7.2 Brief Review of Animal Models in Breast Cancer Research.
- 7.2.1 Definition of an Animal Model.
- 7.2.2 The Rat.
- 7.2.3 The Mouse.
- 7.2.4 The Dog.
- 7.2.5 The Cat.
- 7.2.6 Nonhuman Primates.
- 7.2.7 Other Species.
- 7.2.8 Conclusions.- Summary.- Acknowledgments.- References.

Innenansichten

EAN: 9780898386240
ISBN: 0898386241
Untertitel: A histopathological study of radiation- and hormone-induced rat mammary tumors. 1984. Auflage. Book. Sprache: Englisch.
Verlag: Springer
Erscheinungsdatum: Januar 1984
Seitenanzahl: 302 Seiten
Format: gebunden
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