Small Animal Models of Gal-Mediated and Xenograft Rejection
BeschreibungXenotransplantation offers a potential solution to the worldwide shortage of human tissue available for transplantation. The main immunological barrier to xenografting from pig-to-primate is the antigen, Galactose-alpha-1,3-Galactose (Gal) which is found in all species except humans and other higher primates. Even with the major advancement of deleting Gal from the pig with the aid of cloning technology, complete elimination may be elusive as alternative genes may still produce Gal at low-levels. Thus, the human anti-Gal immune response may continue to be a barrier to successful xenotransplantation. The aim of this book is to demonstrate small animal models of the important components of xenograft rejection and to provide insights into the immune mechanisms of hyperacute, acute vascular and chronic xenograft-like rejection. Both vascularised heart grafts and non-vascularised skin graft models are examined as rejection of solid organs may differ from cellular transplantation. The models of rejection provide a platform for future studies in testing genetic and pharmacological strategies to overcome the xenograft rejection.
PortraitHilton Gock, MBBS(Hons), PhD, FRACP, is a Consultant Nephrologist at St Vincent`s Hospital Melbourne & Honorary Senior Lecturer, Department of Medicine, University of Melbourne, Australia. His doctorate research with the mentorship of accomplished xenotransplant researcher, A.J.F. D`Apice won him the inaugural T.J. Martin Medal in 2005.
Untertitel: Deciphering the Immunology of Cross-species Tissue Transplantation. Paperback. Sprache: Englisch.
Verlag: VDM Verlag
Erscheinungsdatum: Juli 2008
Seitenanzahl: 200 Seiten