MRI and Trials of Neurodegeneration in Multiple Sclerosis

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August 2007



Written by world-renowned scientists, the volume provides a state-of-the-art on the most recent MRI techniques related to MS, and it is an indispensable tool for all those working in this field. The context in which this book exists is that there is an increasing perception that modern MR methodologies should be more extensively employed in clinical trials to derive innovative information.


Background: 1 Neuropathological Advances in Multiple Sclerosis.- 2 Neurophysiology.- MRI Techniques to Assess Neurodegeneration: 3 Atrophy.- 4 T1 Black Holes and Gray Matter Damage.- 5 Magnetization Transfer Imaging.- 6 Perfusion MRI.- 7 Diffusion-Weighted Imaging.- 8 Proton MR Spectroscopy.- 9 Functional MRI.-Evaluation of MRI Outcomes: 10 Validation of MRI Surrogates.- 11 Defining Responders and Non-responders.-12 Predictive Models in Multimodal Imaging.- Lessons from other Neurodegenerative Diseases: 13 Alzheimer's Disease.- 14 Other Neurodegenerative Conditions.- 15 Incorporation of Other Biomarkers.- Designing MS Trials for Neurodegeneration.- 16 Critical Review of Existing Trials.- 17 Design for the Next Trials of Neurodegeneration.- Subject Index


Dr. Massimo Filippi was born in 1961, took his Graduation in Medicine in 1986 and his Post-Degree Graduation in Neurology in 1990. His research activity has always been focussed on the use of MR-based technology to improve our understanding of how neurological diseases determine progressive accumulation of irreversible physical disability and cognitive impairment.
Dr. Filippi is member of various Scientific Societies and, in some of them, he covered or is covering institutional roles. He is also member of the Editorial Boards of many international scientific journals and acts as a reviewer on a regular basis for several others. He is author or co-author of more than 450 scientific papers published on peer-reviewed journals.
Dr. Filippi is currently Dierctor of the Neuroimaging Research Unit (NRU), Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, where he is also Non-Tenured Professor of Clinical Neurology. From 2005 he is also Director of the NMR Unit, Centro "S. Maria Nascente" IRCCS Fondazione Don Gnocchi, Milan.


From the reviews:
"This book is to 'provide a complete and up-to-date overview of the technical, methodological, and clinical issues related to the application of MR imaging in MS trials of neurodegeneration.' ... the strength of this compact book would be its value as a compilation of material that is not so much novel as it is difficult to find in a single volume. ... It will provide a convenient reference resource for MS investigators interested in the current status of neurodegeneration imaging studies in MS ... ." (American Journal of Neuroradiology, Vol. 29, October, 2008)
EAN: 9788847003903
ISBN: 8847003903
Untertitel: 'Topics in Neuroscience'. Auflage 2007. Sprache: Englisch.
Verlag: Springer-Verlag GmbH
Erscheinungsdatum: August 2007
Seitenanzahl: XI
Format: gebunden
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