Thermodynamic Theory of Site-Specific Binding Processes in Biological Macromolecules

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Dezember 2004



This book provides the first systematic treatment of the thermodynamic theory of site-specific effects in biological macromolecules. It describes the phenomenological and conceptual bases required to allow a mechanistic understanding of these effects from analysis of experimental data. The thermodynamic theory also results in novel experimental strategies that enable the derivation of information on local, site-specific properties of a macromolecular system from analysis of perturbed global properties. The treatment focuses on binding phenomena, but is amenable to extension both conceptually and formally to the analysis of other cooperative processes, such as folding and helix-coil transitions. This book will interest any scientist involved in structure-function studies of biological macromolecules, or as a text for graduate students in biochemistry and biophysics.


Preface; 1. Statistical thermodynamic foundations; 2. Global binding processes; 3. Local binding processes; 4. Specific cases and applications; 5. Site-specific effects in Ising networks; References; Index.


"...interesting, well written and well organized, and should be of interest to both food biophysicists and biochemists. The text would be a valuable reference at both the senior undergraduate and graduate levels in courses such as food protein chemistry where topics such as ligand binding, genetic engineering and protein unfolding are included." Rickey Yada, Journal of Food Biochemistry
EAN: 9780521619752
ISBN: 0521619750
Untertitel: Pbk. Sprache: Englisch.
Erscheinungsdatum: Dezember 2004
Seitenanzahl: 316 Seiten
Format: kartoniert
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