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Optical Mapping of Cardiac Excitation and Arrhythmias

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Dezember 2001

Beschreibung

Beschreibung

The recent explosion of knowledge in the cardiovascular field has been fueled by the development of powerful and novel technologies for assessing cardiovascular function and disease. Fluorescent imaging techniques in the heart are a major example.Despite its widespread use in basic research and implications to clinical cardiac electrophysiology, there are no definitive and authoritative sources of information on cardiac optical mapping. This is the first and only book to date that comprehensively, in a single volume, covers all aspects of the technique and application of optical mapping in the heart. Written by leading international experts in the discipline, the book contains the basic principles of optical mapping, including: voltage-sensitive fluorescence, optics, imaging, and high speed computer data acquisition. In addition to providing a primer on basic principles, the book's four main sections cover applications of optical mapping to our understanding of impulse propagation in the heart, cardiac arrhythmias, and cardiac defibrillation. Commentary is provided throughout the book from leaders in the field of clinical cardiac electrophysiology regarding implications to our understanding of arrhythmia mechanisms in patients.This book is essential for scientists, cardiac clinicians, and trainees of all backgrounds who are interested in state-of-the-art imaging approaches to biology, as well as for the investigator who is thinking about establishing an optical mapping system in his/her lab.

Inhaltsverzeichnis

Foreword Mark E. Josephson Glossary Section I. Basic Principles Introduction: Optical Mapping of Cardiac Excitation and Arrhythmias: A Primer David S. Rosenbaum 1. Optical Mapping: Background and Historical Perspective Guy Salama 2. Mechanisms and Principles of Voltage-Sensitive Fluorescence Leslie M. Loew 3. Optical Properties of Cardiac Tissue William T. Baxter 4. Optics and Detectors Used in Optical Mapping Kenneth R. Laurita and Imad Libbus 5. Optimization of Temporal Filtering for Optical Transmembrane Potential Signals Francis X. Witkowski, Patricia A. Penkoske, and L. Joshua Leon Section II. Microscopic Propagation Introduction: Unique Role of Optical Mapping in the Study of Propagation and Repolarization David S. Rosenbaum 6. Optical Mapping of Impulse Propagation within Cardiomyocytes Herbert Windisch 7. Optical Mapping of Impulse Propagation between Cardiomyocytes Stephan Rohr and Jan P. Kucera 8. Role of Cell-to-Cell Coupling, Structural Discontinuities, and Tissue Anisotropy in Propagation of the Electrical Impulse Andre G. Kleber, Stephan Rohr, and Vladimir G. Fast 9. Optical Mapping of Impulse Propagation in the Atrioventricular Node: 1 Todor N. Mazgalev and Igor R. Efimov 10. Optical Mapping of Impulse Propagation in the Atrioventricular Node: 2 Guy Salama and Bum-Rak Choi 11. Optical Mapping of Microscopic Propagation: Clinical Insights and Applications Albert L. Waldo Section III. Cardiac Arrhythmias Introduction: Unique Role of Optical Mapping in the Study of Cardiac Arrhythmias Jose Jalife 12. Mapping Arrhythmia Substrates Related to Repolarization: 1. Dispersion of Repolarization Kenneth R. Laurita, Joseph M. Pastore, and David S. Rosenbaum 13. Mapping Arrhythmia Substrates Related to Repolarization: 2. Cardiac Wavelength Steven Girouard and David S. Rosenbaum 14. Video Imaging of Cardiac Fibrillation Richard A. Gray and Jose Jalife 15. Video Mapping of Spiral Waves in the Heart William T. Baxter and Jorge M. Davidenko 16. Video Imaging of Wave Propagation in a Transgenic Mouse Model of Cardiomyopathy Faramarz Samie, Gregory E. Morley, Dhjananjay Vaidya, Karen L. Vikstrom, and Jose Jalife 17. Optical Mapping of Cardiac Arrhythmias: Clinical Insights and Applications Douglas L. Packer Section IV. Cardiac Defibrillation Introduction: Unique Role of Optical Mapping in the Study of Cardiac Defibrillation Jose Jalife 18. Response of Cardiac Myocytes to Electrical Fields Leslie Tung 19. New Perspectives in Electrophysiology from The Cardiac Bidomain Shien-Fong Lin and John P. Wikswo, Jr. 20. Mechanisms of Defibrillation: 1. Influence of Fiber Structure on Tissue Response to Electrical Stimulation Stephen B. Knisley 21. Mechanisms of Defibrillation: 2. Application of Laser Scanning Technology Stephen M. Dillon 22. Mechanisms of Defibrillation: 3. Virtual Electrode-Induced Wave Fronts and Phase Singularities; Mechanisms of Success and Failure of Internal Defibrillation Igor R. Efimov and Yuanna Cheng 23. Optical Mapping of Cardiac Defibrillation: Clinical Insights and Applications Douglas P. Zipes Index

Pressestimmen

"This unique book...bridges the gap between basic science and clinical electrophysiology."William C. RobertsAmerican Journal of Cardiology
EAN: 9780879934811
ISBN: 0879934816
Untertitel: New. Sprache: Englisch.
Verlag: FUTURA PUB CO INC
Erscheinungsdatum: Dezember 2001
Seitenanzahl: 458 Seiten
Format: gebunden
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