Viruses and the Nucleus

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April 2006



Viruses have limited genome-coding capacities and must therefore rely on their host cells to facilitate every step of the infection cycle from the replication of their genomes, transcription and translation of mRNAs to virus assembly. Aimed at virologists and cell biologistsViruses and the Nucleus provides a comprehensive and cohesive overview of this fascinating and fast moving field. It compares and contrasts the ways in which DNA viruses, retroviruses and RNA viruses interact with the host cell nucleus to bring about replication and how they subvert the host cell function to proliferate and survive.
Written by a team of leading experts in the field, this multi-authored text begins with an introduction to the key nuclear process that effect virus biology including cell cycle, transcription, splicing and protein trafficking. It then goes on to explore the advances that have been made in understanding the ways in which specific viruses interact with nuclear sub-structures such as the nucleolus and ND10s, and the implications this interrelationship has for the cell cycle as a whole.
Key Features
* Comprehensive cross disciplinary coverage of the interrelationship between cell biology and virology.
* Written by leading experts, this authorative book provides an up to date overview of this highly active field.
* Covers the latest research areas including virus interactions with sub-nuclear structures, virus protein trafficking into and out of the nucleus and subversion of host-cell function through specific nuclear interactions.
Viruses and the Nucleus will be an invaluable resource for students of virology, microbiology and cell biology as well as those who work within the industry.


1. The Nucleus - An Overview (Dean A. Jackson).
1.1 Introduction.
1.2 The gene expression pathway in mammalian cells.
1.3 Chromosome structure and DNA loops.
1.4 Duplicating the genetic code.
1.5 Nuclear Compartmentalization.
1.6 Nuclear Architecture - implications for viral infections.
1.7 Conclusion.
2. The Eukaryotic Cell Cycle (Jane V. Harper and Gavin Brooks).
2.1 Introduction.
2.2 The G0/G1 transition.
2.3 The G1-S transition.
2.4 S Phase.
2.5 The G2-M transition.
2.6 Mitosis (M-Phase).
2.7 Cytokinesis.
2.8 Endoreduplication.
2.9 Summary and Conclusions.
3. DNA Viruses and the Nucleus (G. Eric Blair and Nicola James).
3.1 Introduction.
3.2 The structure of the nucleus.
3.3 DNA Viruses and the nucleus.
3.4 Concluding comments and future directions.
4. Retroviruses and the nucleus (Carlos De Noronha and Warner C. Greene).
4.1 Retroviral structure.
4.2 The retroviral life cycle.
4.3 Entering the nucleus.
4.4 Inside the nucleus.
4.5 Leaving the nucleus and the cell.
4.6 Future Perspectives.
5. Negative-sense RNA Viruses and the Nucleus (Debra Elton and Paul Digard).
5.1 Introduction.
5.2 The necessity of a nucleus.
5.3 Nuclear import machinery.
5.4 The cellular transcription machinery.
5.5 Nuclear architecture.
5.6 Nuclear export.
5.7 Evasion of innate antiviral responses.
6. Positive-Strand RNA Viruses and the Nucleus (Kurt E. Gustin and Peter Sarnow).
6.1 Introduction.
6.2 Replication of positive-strand RNA viruses in enucleated cells.
6.3 Localization of viral proteins to the nucleus.
6.4 Interaction of nuclear factors with viral proteins and nucleic acids.
6.5 Cytoplasmic accumulation of nuclear proteins during infection.
6.6 Disruption of nucleo-cytoplasmic trafficking by positive-strand RNA viruses.
6.7 Advantages provided to the virus by inhibiting nuclear import.
6.8 Conclusions.
7. Viruses and the Nucleus (David A. Matthews and Julian A. Hiscox).
7.1 Introduction.
7.2 Techniques used to examine the nucleolus.
7.3 Nucleolar localization signals (NoLS).
7.4 Viral interactions with the nucleolus.
7.5 The nucloelus, viruses and autoimmunity.
7.6 Summary.
8. Virus Interactions with PML Nuclear Bodies (Keith N. Leppard and John Dimmock).
8.1 Introduction.
8.2 ND10 in uninfected cells.
8.3 Functions of ND10.
8.4 ND10 and virus infection.
8.5 Why do viruses interact with and modify ND10?.
9. Viruses and the Cell Cycle (Crisanto Gutierrez, Brian Dove and Julian A. Hiscox).
9.1 Introduction: An the overview of the eukaryotic cell cycle.
9.2 Retroviruses and the cell cycle.
9.3 RNA viruses and the cell cycle.
9.4 Viruses, the nucleolus and cell cycle control.
9.5 Viral interaction with aviator protein-1 (AP-1).
9.6 Summary.


Dr. Julian Alexander Hiscox, School of Biochemistry and Molecular Biology, University of Leeds, UK.
EAN: 9780470851135
ISBN: 0470851139
Untertitel: 1. Auflage. Sprache: Englisch.
Erscheinungsdatum: April 2006
Seitenanzahl: 283 Seiten
Format: kartoniert
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