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Stem Cells and CNS Development

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Februar 2001

Beschreibung

Beschreibung

Stem Cells and CNS Development critically reviews recent findings on stem cells, their involvement in neurogenesis and gliogenesis, and the therapeutic implications of these findings. It defines by consensus the classes of stem cells in the nervous system, compares their similarities and differences, discusses the gains made in identifying human homologs of neural stem cells, and describes how these cells are beginning to be used for therapeutic purposes. Comprehensive and cutting-edge, this book provides all developmental scientists and neurobiologists not only an authoritative account of the current results in neural stem cell research, but also an incisive review of the rapidly emerging therapeutic uses of stem cells. Stem cells were recently cited by Science magazine as the scientific breakthrough of the year because of their potential to revolutionize our understanding of the complexities of biological development. In Stem Cells and CNS Development, world renowned authorities in neural stem biology critically review the rapidly emerging findings on this critical class of stem cells, their involvement in neurogenesis and gliogenesis, and the therapeutic implications of these findings. The authors define by consensus the classes of stem cells in the nervous system, compare their similarities and differences, discuss the gains made in identifying human homologs of neural stem cells, and describe how these cells are beginning to be used for therapeutic purposes. Their examination includes all the major issues in stem cell biology, save apoptosis and cell cycle regulators. Comprehensive and cutting-edge, Stem Cells and CNS Development provides all developmental scientists and neurobiologists not only an authoritative account of the current results in neural stem cell research, but also an incisive review of the rapidly emerging therapeutic uses of stem cells.

Inhaltsverzeichnis

Defining Neural Stem Cells and Their Role in Normal Development of the Nervous System
Sally Temple

Multipotent Stem Cells in the Embryonic Nervous System
John A. Kessler, Mark F. Mehler, and Peter C. Mabie

Multipotent Stem Cells in the Adult Central Nervous System
Luca Bonfanti, Angela Gritti, Rossella Galli, and Angelo L. Vescovi

Glial Characteristics of Adult Subventricular Zone Stem Cells
Daniel A. Lim and Arturo Alvarez-Buylla

Neuronal Restricted Precursors
Giri Venkatraman and Marla B. Luskin

Glial Restricted Precursors
Mark Noble and Margot Mayer-Pröschel

PNS Precursor Cells
Tanya A. Moreno and Marianne Bronner-Fraser

Neural Progenitor Cells of the Adult Human Brain
Steven A. Goldman

ES Cells and Neurogenesis
John W. McDonald

Mobilizing Endogenous Stem Cells
Theo D. Palmer, Sophia Colamarino, and Fred H. Gage

Transplant Therapy
Barbara A. Tate, Kate A. Bower, and Evan Y. Snyder

Drug Discovery and Gene Discovery
Alexander Kamb and Mahendra S. Rao

Appendix A: Neural Stem Cell Companies
Appendix B: Stem Cells and Transplants
Appendix C: Patents and Stem Cells
Appendix D: Stem Cells and US Federal Guidelines
About the Authors

Pressestimmen

"This is a surprisingly readable book. It is also very informative. Any interested clinician that wants a broad overview of the field should consult this text; so should anyone considering research in this exciting and rapidly developing field." -British Journal of Neurosurgery
EAN: 9780896038868
ISBN: 0896038866
Untertitel: 2001. Auflage. Book. Sprache: Englisch.
Verlag: Humana Press
Erscheinungsdatum: Februar 2001
Seitenanzahl: 384 Seiten
Format: gebunden
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