Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases

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April 2000



The recent dramatic expansion of our knowledge about how cell surface receptors transmit signals to the nucleus, together with the identification of key signaling and cell-cycle-regulating molecules, has provided a major opportunity to search for novel targets for therapeutic intervention in many diseases. In Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases, leading scientists summarize this knowledge and describe the effort to design and synthesize inhibiting molecules, as well as to evaluate their biochemical and biological activities. They review the relevant cell surface receptors, their ligands, and their downstream pathways. Also examined are the latest findings on the components of novel signaling networks controlling the activity of nuclear transcription factors and cell cycle regulatory molecules. Rich in cutting-edge insights and authoritative critical analysis, Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases presents a wealth of information on the emerging principles of the field, as well as an invaluable guide for all experimental and clinical investigators of cell regulation and its rapidly emerging pharmacological opportunities today.


Integrin Signaling, Kenneth M. Yamada and Erik H. J. Danen. Signal Transduction Through Tyrosine Kinase Growth Factor Receptors, Paolo Fedi and Stuart A. Aaronson. Signaling from TGF-b Receptors, Anita B. Roberts, Mark P. de Caestecker, and Robert J. Lechleider. The Wnt Signal Transduction Pathway, Grant D. Barish and Bart O. Williams. Signaling from G-Protein-Coupled Receptors to the Nucleus, Shigetomo Fukuhara, Maria Julia Marinissen, Mario Chiariello, and J. Silvio Gutkind. Proximal Events in T-Cell Activation, Joanne Sloan-Lancaster and Lawrence E. Samelson. Signal Transduction from the High Affinity IgE Receptor, Reuben P. Siraganian. Signaling Through Fas (CD95, APO-1) and Related Death Receptors, Richard M. Siegel, David A. Martin, Felicita Hornung, Erastus C. Dudley, Lixin Zheng, and Michael J. Lenardo. Signal Transduction to the Nucleus by MAP Kinase, Roger J. Davis. The Regulation of MAP Kinase Pathways by MAP Kinase Phosphatases, Kathleen Kelly and Yanfang Chu. Control of MAPK Signaling by Ste20- and Ste11-Like Kinases, Gary R. Fanger, Thomas K. Schlesinger, and Gary L. Johnson. Ras Signaling and Transformation, Geoffrey J. Clark, John P. O'Bryan, and Channing J. Der. Signaling Pathways Controlled by Rho Family GTP-Binding Proteins, Marc Symons. PI3-Kinases: Role in Signal Transduction, David A. Fruman and Lewis C. Cantley. PI3K-Related Kinases: Roles in Cell-Cycle Regulation and DNA Damage Responses, Randal S. Tibbetts and Robert T. Abraham. Integrative Signaling Through c-Abl: A Tyrosine Kinase with Nuclear and Cytoplasmic Functions, Jean Y. J. Wang. Src: A Model for Regulation of Intracellular Signaling Molecules, Pamela L. Schwartzberg. Inhibitors of Protein Kinase C and Related Receptors for the Lipophilic Second Messenger sn-1,2-Diacylglycerol, Peter M. Blumberg, Peter Acs, Dipak K. Bhattacharyya, and Patricia S. Lorenzo. Reactive Oxygen Species in Proliferative Signaling, Toren Finkel and Daniel M. Sullivan. Sphingolipid Metabolites in Signal Transduction, Sarah Spiegel and Sheldon Milstien. The Jak/Stat Signaling Cascade: Its Role in the Biological Effects of Interferons, Andrew C. Larner and Andrew Keightley. Regulation of Cell Growth and Death by p53, Kevin M. Ryan and Karen H. Vousden. Regulation of NF-kB Function: Novel Molecular Targets for Pharmacological Intervention, Frank Mercurio and Anthony M. Manning. Using Protein-Interaction Domains to Manipulate Signaling Pathways, Bruce J. Mayer. Protein Tyrosine Kinase Inhibitors as Novel Therapeutic Agents, Alexander Levitzki. A Pharmacological Approach to the MAP Kinase Cascade, David T. Dudley and Alan R. Saltiel. Specific Inhibitors of p38 MAP Kinase, Peter R. Young. Farnesyltransferase Inhibitors: Anti-Ras or Anticancer Drugs?, Adrienne D. Cox and Channing J. Der. Targeted p53 Gene Therapy-Mediated Radiosensitization and Chemosensitization, Esther H. Chang, Liang Xu, and Kathleen F. Pirollo. Treatment of p53-Deficient Cancers by Adenovirus E1B-Region Mutants: From Basic Research to the Clinic, David H. Kirn. The Cell Cycle Inhibitor p27 as a Prognostic Marker in Human Tumors and a Novel Target for Therapeutic Intervention, Michele Pagano and Katya Ravid. Chemical Cyclin-Dependent Kinase Inhibitors: Therapeutic Implications, Edward A. Sausville and Adrian M. Senderowicz. Index.


"Each chapter contains a well-referenced, clearly illustrated and up-to-date summary of the state of affairs including a discussion of the areas that are still open for further work. The volume provides a good read for both workers actively engaged in drug research as well as those working in the more fundamental areas of signaling and the cell cycle." - Cell Biology and Function
"...the range of topics included in this book is impressive....This volume works well on many levels. For graduate students struggling to assimilate the large body of signaling literature, the first half of the book offers what amounts to a comprehensive review of the most basic aspects of signal transduction. For experts, these same chapters serve as a point of departure for the second half, which deals with the emerging body of literature on how one can manipulate signaling pathways in the treatment of disease. It is the combination of basic and applied aspects of signal transduction that makes this book unique....the editor has done a remarkable job in selecting and assembling reviews from experts in signal transduction, and for presenting such a lucid discussion of this complex field." - Quarterly Review of Biology
"Each chapter is well referenced and stands alone as a comprehensive review in a specific area of signaling networks and cell-cycle control. In many cases the authors have highlighted several areas that are still open for further investigation, and have attempted to define the most likely molecular targets for pharmacological intervention...I would recommend this as a must have reference book, aimed mainly at an expert audience, which any good academic or biotechnological company library should have." - Cell Biology International
EAN: 9780896037106
ISBN: 089603710X
Untertitel: The Molecular Basis of Cancer and Other Diseases. 'Cancer Drug Discovery & Develo'. 2000. Auflage. Sprache: Englisch.
Erscheinungsdatum: April 2000
Seitenanzahl: 578 Seiten
Format: gebunden
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