Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease

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Januar 2015



This volume of the Subcellular Biochemistry series is the result of the long-standing research interest of the editor in the molecular mechanism underlying Alzheimer's disease and other amyloid diseases, indicated also by the earlier book in the series (Volume 38), devoted to Alzheimer's disease. The broad coverage within the present amyloidogenesis book represents an attempt to collate current knowledge relating to the proteins and peptides involved in most of the known amyloid diseases, together with some amyloid/fibril-forming proteins and peptides that are not involved in diseases. Thus, the range of topics included is comprehensive and furthermore it was thought appropriate to include both basic science and clinical presentation of the subjects under discussion.


I. Introduction1. Introduction and Technical Survey; J. Robin Harris and Nathaniel G. Milton II. Basic Science2. Fibril Formation by Short Synthetic Peptides; Andrew Smith 3. In vitro Oligomerization and Fibrillogenesis of Amyloid-beta Peptides; Núria  Benseny-Cases, Oksana Klementieva and Josep Cladera4. Tau Fibrillogenesis; Nitin Chaudhary and Ramakrishnan Nagaraj5. Prion protein Aggregation and Fibrillogenesis In vitro; Jan Stöhr6. a-Synuclein Aggregation and Modulating Factors; Katerina E. Paleologou and Omar M. A. El-Agnaf7. Pathological Self-aggregation of ß2-microglobulin: A Challenge for Protein Biophysics; Gennaro Esposito, Alessandra Corazza, and Vittorio Bellotti8. Islet amyloid polypeptide - Aggregation and fibrillogenesis in vitro and its Inhibition; Janine Seeliger and Roland Winter9. Mechanisms of Transthyretin Aggregation and Toxicity; Robert J. Gasperini, David W. Klaver, Xu Hou, Marie-Isabel Aguilar and David H. Small10. Fibrillogenesis of Huntingtin and Other Glutamine Containing Proteins; Yuri L. Lyubchenko, Alexey V. Krasnoslobodtsev and Sorin Luca11. Aggregation and Fibrillogenesis of Proteins not Associated with Disease - A few Case Studies; Moritz Lassé, Juliet A. Gerrard and  F. Grant Pearce12. Experimental Inhibition of Peptide Fibrillogenesis by Synthetic Peptides, Carbohydrates and Drugs; Alagiri Srinivasan13. Experimental inhibition of fibrillogenesis and neurotoxicity by amyloid-beta (Aß) and other disease-related peptides/proteins by plant extracts and herbal compounds; Suresh Kumar, Edward  Okello and J. Robin HarrisIII. Clinical Science: The Cerebral and Systemic Amyloid DiseasesPathogenesis and therapeutic consideration of the major disorders14. Alzheimer's  Disease; Vanessa J. De-Paula, Marcia Radanovic, Breno S. Diniz, Orestes V. Forlenza15. Modeling the Polyglutamine Aggregation Pathway in Huntington's Disease: from Basic Studies to Clinical Applications; Keizo Sugaya16. Parkinson's Disease; Timothy R. Mhyre, James T. Boyd, Robert W.  Hamill, and Kathleen Maguire-Zeiss17. Human Prion Diseases: From Kuru to Variant Creutzfeldt-Jakob Diseasae; Beata Sikorska and Pawel P. Liberski18. Animal Prion Diseases; Otto Windl and Mike Dawson19. ß2-microglobulin Amyloidosis; Dorthe B. Corlin and Niels H.H. Heegaard20. Systemic AA Amyloidosis; Jennifer H Pinney and Helen J Lachmann21. Familial Amyloidotic Polyneuropathy and Transthyretin; Takamura Nagasaka 22. The Challenge of Systemic Immunoglobulin Light-chain Amyloidosis (AL); Giovanni Palladini and Raymond L Comenzo


EAN: 9789400797369
ISBN: 9400797362
Untertitel: 2012. Auflage. Previously published in hardcover. Sprache: Englisch.
Verlag: Springer
Erscheinungsdatum: Januar 2015
Seitenanzahl: 668 Seiten
Format: kartoniert
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