HUDU

Peptides as Drugs


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Juni 2009

Beschreibung

Beschreibung

By covering the full spectrum of topics relevant to peptidic drugs, this timely handbook serves as an introductory reference for both drug developers and biomedical researchers interested in pharmaceutically active peptides, presenting both the advantages and challenges associated with this molecular class. The first part discusses current approaches to developing pharmaceutically active peptides, including case studies of the use of peptidic drugs in cancer and AIDS therapy. The second part surveys strategies for the development and targeting of peptidic drugs. With its integration of biochemical, pharmaceutical and clinical research, this work reveals the full picture of modern peptide drug research in a single volume, making it an invaluable reference for medicinal chemists, biochemists, biotechnologists, and those in the pharmaceutical and biotechnological industries.

Inhaltsverzeichnis

PEPTIDES AS DRUGS: DISCOVERY AND DEVELOPMENT
Discovery of New Potential Drug Targets and the Limitations of Druggability
Protein Interaction Domains are at the Core of Signaling Pathways
Peptides as Inhibitors of Protein Interactions
MIMICS OF GROWTH FACTORS AND CYTOKINES
Introduction
The Cytokines
Defining Receptor Recognition Sites in Cytokines Using Chimeric Proteins
Receptor Recognition Sites are Organized as Exchangeable Modules
The Concept of Fusing the Cytokine to the Soluble Receptor: Hyper-IL-6
Antagonists Specifically Inhibiting IL-6 Trans-Signaling
In Vitro Evolution of Peptides and Proteins
PEPTIDES DERIVED FROM EXON v& OF THE CD$$ EXTRACELLULAR DOMAIN PREVENT ACTIVATION OF RECEPTOR TYROSINE KINASE AND SUBSEQUENTLY ANGIOGENESIS AND METASTATIC SPREAD OF TUMOR CELLS
Introduction
CD44 Proteins and Their Involvement in RTK Activation
CD44v6 Acts as a Coreceptor for c-Met and Ron
Three Amino Acids in CD44 Exon v6 are Crucial for the CD44v6 Coreceptor Function, and Small Peptides Can Interfere with This Function
The Ectodomain of CD44v6 Binds to HGF
Peptides Corresponding to Exon v6 of CD44 Inhibit Metastatic Spread of Tumor Cells
The Significance of the Collaboration Between CD44v6 and c-Met In Vivo
The CD44v6 Peptides Interfere with Angiogenesis
PEPTIDE APTAMERS TARGETING THE VIRAL E6 ONCOPROTEIN INDUCE APOPTOSIS IN HPV-POSITIVE CANCER CELLS
Human Papillomaviruses and Oncogenesis
Peptide Aptamers Targeting the HPV E6 Oncoprotein
E6-Targeting Peptide Aptamers: Therapeutic Perspectives
Perspectives
THE PREVENTION OF HIV INFECTION WITH VIRAL ENTRY INHIBITORS
Introduction: The Potential of Peptides as Drugs in the Treatment of HIV Infection
The HIV Entry Process
Peptides that Inhibit Receptor or Coreceptor Binding
Inhibitors of the Viral and Cellular Membrane Fusion Process
Entry Inhibitory Peptides Selected by the Phage Display Technology
Limitations of Peptides it the Treatment of HIV Infection
Strategies to Prolong the In Vivo Half-Life of Antiviral Peptides
Antiviral Peptides in Gene Therapy of HIV Infection
INTRACELLULAR EXPRESSION OF PEPTIDES
Introduction
Peptide Design and Expression Cassettes
Stable Delivery and Expression of Peptides: Gamma-Retro- and Lentiviral Vectors
Gamma-Retroviral Vectors
Lentiviral Peptide Delivery
Vectors for Transient Expression of Peptides: Adenoviruses and Adeno-Associated Viruses
Perspective
THE INTERNALIZATION MECHANISMS AND BIOACTIVITY OF THE CELL-PENETRATING PEPTIDES
Introduction
Discovery and Classification of CPPs
Internalization Mechanisms of Cell-Penetrating Peptides
Models of CPP Uptake
The Current View of CPP Uptake
CPPs as Cargo Delivery Vehicles
Delivery of Proteins
CPPs in Gene Delivery
Delivery of Oligonucleotides
Cytotoxicity of Cell-Penetrating Peptides
In Vivo Drug Delivery with CPPs
CPPs for Targeted Delivery
PRODUCTION AND PURIFICATION OF MONOMERIC RECOMBINANT PEPTIDE APTAMERS: REQUIREMENTS FOR EFFICIENT INTRACELLULAR UPTAKE AND TARGET INHIBITION
Introduction
Protein Production
Protein Purification
Isolation of Monomeric, Natively Folded Proteins
Increasing Peptide Production, Purification and Efficacy by Using Scaffolds
The Use of Cell-Penetrating Peptides for Cellular Uptake of Purified Proteins
Classification of Therapeutic Peptides
Production and Administration of Therapeutic Peptides In Vivo
PEPTIDE ARRAYS ON SOLID SUUPORTS: A TOOL FOR THE IDENTIFICATION OF PEPTIDE LIGANDS
Introduction
Synthesis of Peptide Arrays
Applications of Peptide Arrays
Challenges in High-Throughput Screening (HTS)
Future Perspectives

Portrait

Bernd Groner is the head of the Georg Speyer Haus, an independent biomedical research institute in Frankfurt am Main (Germany). He studied biochemistry at the University of Pittsburgh (USA) and did postdoctoral work at Columbia University in New York, the Max-Planck-Institute for Molecular Genetics in Berlin, and the Swiss Institute for Experimental Cancer Research in Lausanne. From 1993 to 1998, he served as Director of the Institute for Experimental Cancer Research in Freiburg (Germany), before taking up his current post at the Georg Speyer Haus. He is a widely recognized authority on peptide hormones and has pioneered the design of peptides as pharmacological modulators of cell signaling.
EAN: 9783527322053
ISBN: 3527322051
Untertitel: Discovery and Development. 1. Auflage. 35 schwarz-weiße und 3 farbige Abbildungen, 8 schwarz-weiße Tabellen. Sprache: Englisch.
Verlag: Wiley VCH Verlag GmbH
Erscheinungsdatum: Juni 2009
Seitenanzahl: XVI
Format: gebunden
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