Pathogenesis of Neurodegenerative Disorders

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Juni 2001



As the average life expectancy of many populations throughout the world increases, so to does the incidence of such age-related neurodegenerative disorders as Alzheimer's, Parkinson's, and Huntington's diseases. Rapid advances in our understanding of the molecular genetics and environmental factors that either cause or increase risk for age-related neurodegenerative disor­ ders have been made in the past decade. The ability to evaluate, at the cellular and molecular level, abnormalities in postmortem brain tissue from patients, when taken together with the development of valuable animal and cell-culture models of neurodegenerative disorders has allowed the identification of sequences of events within neurons that result in their demise in specific neurodegenerative disorders. Though the genetic and environmental factors that pro­ mote neurodegeneration may differ among disorders, shared biochemical cascades that will ultimately lead to the death of neurons have been identified. These cascades involve oxyradical production, aberrant regulation of cellular ion homeostasis and activation of a stereotyped sequence of events involving mitochondrial dysfunction and activa­ tion of specific proteases. Pathogenesis of Neurodegenerative Disorders provides a timely compilation of articles that encompasses fundamental mechanisms involved in neurodegenerative disorders. In addition, mechanisms that may prevent age-related neurodegenerative disorders are presented. Each chapter is written by an expert in the particular neurodegenerative disorder or mechanism or neuronal death discussed.


Mechanisms of Neuronal Apoptosis and Excitotoxicity
Mark P. Mattson

Oxidative Alterations in Neurodegenerative Diseases
William R. Markesbery, Thomas J. Montine, and Mark A. Lovell

Parkinson's Disease
M. T. Silva and A. H. V. Schapira

Scope of Trinucleotide Repeat Disorders
Shoji Tsuji

Mechanisms of Neuronal Death in Huntington's Disease
Vassilis E. Koliatsos, Carlos Portera-Cailliau, Gabrielle Schilling, David B. Borchelt, Mark W. Becher, and Christopher A. Ross

Cellular and Molecular Mechanisms Underlying Synaptic Degeneration and Neuronal Death in Alzheimer's Disease
Mark P. Mattson, Ward A. Pedersen, and Carsten Culmsee

Oxidative Stress in Down Syndrome: A Paradigm for the Pathogenesis of Neurodegenerative Disorders
Rocco C. Iannello and Ismail Kola

The Pathogenesis of Amyotrophic Lateral Sclerosis
Stanley H. Appel and R. Glenn Smith

Experimental Genetics as a Tool for Understanding Pathogenesis of ALS
Philip C. Wong, Donald L. Price, and Jamuna Subramaniam

Pathogenesis of Ischemic Stroke
Mark P. Mattson and Carsten Culmsee

Spinal-Cord Injury
Isabel Klusman and Martin E. Schwab

The Pathogenesis of Duchenne Muscular Dystrophy
Edward A. Burton and Kay E. Davies


"...a timely collection of 12 papers authored by 26 experts...mechanisms combined with specific molecular genetic and environmental factors are responsible for the development of the diseases that are covered in a concise...manner in subsequent chapters...The chapter on "Trinucleotide Repeat Disorders" provides fascinating reading...The 12 chapters are balanced in length, are all well referenced, and provide a state of the art summary for those who are only tangentially involved in studying these disorders or treating patients suffering from any of them. On the other hand, for those whose main interest lies in research related to any of these diseases, it is a refreshing, well-written, and well-edited overview of a field that evolves and changes at unprecedented speed....With the help of well-known experts in the relevant fields, several basic pieces of the puzzle are provided that with the appropriate intellectual efforts can be sewn together. The result is the emergence of an overall view, the "Big Picture."...the overall value of the book is undeniable, and it is beyond doubt that it will serve as a major reference source for neurologists, neuropathologists, and residents training in the respective fields." - Modern Pathology
"A wide range of conditions and illnesses are covered, including ALS, muscular dystrophy, Parkinson's, Huntington's, Alzheimer's, Down's, stroke, and spinal cord trauma. Whole articles are devoted to neurogenetic mechanisms, oxidative processes, excitotoxicity, and apoptosis. From the viewpoint of a general clinical neurologist, the best feature of this book is that it is, for the most part, an understandable summary and update of the neuroscience that was not yet discovered a few years ago. The illustrations are of good quality...This book is good for a clinician because it broadens one's horizons and gives the clinician a better ability to help patients understand their problems. It would be good for a researcher or a graduate student because it summarizes what is being done in many fields." -Doody's Health Sciences Book Review Journal
"This handy pocket guide will be useful for many residents and clinicians, especially in those specialties that treat Alzheimer's disease. It is a worthy addition to departmental and hospital libraries and, predictably, will be used quite frequently." - The Canadian Journal of Neurological Sciences
EAN: 9780896038387
ISBN: 0896038386
Untertitel: 2001. Auflage. Sprache: Englisch.
Erscheinungsdatum: Juni 2001
Seitenanzahl: 294 Seiten
Format: gebunden
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