Endocrinology of Breast Cancer

€ 284,99
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Januar 1999



A cutting-edge review of how derangements in the hormonal and growth factor mechanisms controlling normal mammary development lead to breast cancer. Drawing on the multidisciplinary expertise of leading authorities, the book highlights the roles of oncogenes and tumor suppressor genes, spelling out the importance of autocrine/paracrine loops (e.g., stromal epithelial interactions) in supporting breast cancer cell proliferation and the progression to hormone independence. The book's many prominent contributors also illuminate significant recent advances in the biochemistry and physiology of hormone receptors and review the state-of -the-art in the endocrine therapy of breast cancer. Endocrinology of Breast Cancer provides a unique integrated overview of the most significant basic and clinical developments concerning the hormonal aspects of breast cancer.


Part I. Hormonal Control of Mammary Development and Growth. Hormonal Control of Normal Breast Morphology and Function, Richard E. Blackwell and Karen R. Hammond. Interactions Between Estradiol and Progesterone in Normal Breast: Implications for Mammary Carcinogenesis, Geneviève Plu-Bureau, Philippe Touraine, and Pierre Mauvais-Jarvis. Expression and Regulation of Insulin-like Growth Factors and Their Binding Proteins in the Normal Breast, Monica M. Richert and Teresa L. Wood. Part II. Carcinogenesis. Estrogens and Breast Cancer: An Epidemiologic Perspective, Heather Spencer Feigelson and Brian E. Henderson. Androgens, Estrogens, and Breast Cancer Risk, V. H. T. James. Local Estrogen Production: Is Aromatase an Oncogene, Rajeshwar Rao Tekmal and Richard J. Santen. Oncogenes and Mammary Carcinogenesis, Maria Luisa Veronese, Florencia Bullrich, and Carlo M. Croce. Categorization of Breast Cyst Fluid and Breast Cancer Risk, Luigi Dogliotti and Pasquale Caraci. Part III. Tumor Progression. The Role of Tumor Suppressor Genes in Breast Cancer Progression, Robert Callahan. Oncogene Activation and Breast Cancer Progression, Richard J. Pietras and Mark D. Pegram. Interactions Between Stroma and Epithelium in Breast Cancer: Implications for Tumor Genesis, Growth, and Progression, Kevin J. Cullen, Sahana S. Kaup, and Audrey A. Rasmussen. The Role of Angiogenesis in the Transition to Hormone Independence and Acquisition of the Metastatic Phenotype, Francis G. Kern. Role of the IGF System in Breast Cancer Proliferation and Progression, A. V. Lee and D. Yee. Prognostic and Predictive Factors in Breast Cancer, Jan G. M. Klijn, Els M. J. J. Berns, and John A. Foekens. Role of the Polyamine Pathway in the Natural History of Breast Cancer, Andrea Manni. Aromatase Inhibitors in Breast Carcinoma, Harold A. Harvey. Part IV. Hormone Receptors and Their Functions. Role of Progestins and Progesterone Receptors in Breast Cancer Biology, Anne Guiochon-Mantel and Edwin Milgrom. Prolactin andits Receptors in Human Breast Cancer, Barbara K. Vonderhaar. Part V. Endocrine Therapy of Breast Cancer. Pharmacology and Use of Antiestrogens in Treatment and Chemoprevention of Breast Cancer, William J. Gradishar and V. Craig Jordan. LHRH Superagonists and Antagonists in the Treatment of Breast Cancer, P. N. Mainwaring and M. Dowsett. Part VI. Benign Breast Disease. Benign Breast Lesions: Pathologic Classification and Risk Potential, Roy A. Jensen. Hormonal Treatment of Fibrocystic Disease, Luigi Dogliotti and Pasquale Caraci. Gynecomastia and Galactorrhea, David L. Kleinberg. Index.


"A variety of topics are covered, including carcinogenesis, tumor progression, therapeutic options, and benign breast disease. The section divisions of the book make it easy to locate topics of interest. Each chapter has an extensive list of references for further study. Parts IV and V are very thorough in reviewing targets for therapy and endocrine therapy. These chapters provide a good basis from which to understand the development of endocrine therapies. The discussion of normal breast physiology and development is beneficial for the less specialized physician and helps to round out the discussion. "-Doody's Health Science Book Review Journal
" invaluable resource for both basic scientists and clinicians who need to update their knowledge about breast cancer biology..."-Cell Biology International 2000
"The authors have succeeded in exploring the most important cell physiology and molecular biology issues pertaining to m endocrinology of breast cancer. For example, there are detailed chapters exploring the relationship between both oncogenes and tumor suppressor genes and breast cancer induction and progression. In addition this volume contains detailed, yet concise, chapters pertaining to the prediction of breast cancer, chemoprevention, and the most novel hormonal treatment strategies. The editor and the authors have clearly worked together to create a focused, yet thorough chapters with minimal overlap, and maximum synergy among chapters" -Quarterly Review of Biology
"...will serve as a comprehensive reference for students, physicians in training, practitioners and investigators....I found the book most helpful as an encyclopedia description of the subject matter. ...I give DR. Manni high marks for having pulled it all together. The goal was to furnish a new state-of-the-art, reference text to fill an important gap." -Elsevier Science
"If you are very interested in the endocrinology of breast development and disease, there probably is no other book available that deals with this area as completely and as currently as this one. Thus, it is a significant contribution to the breast literature."-Modern Pathology
EAN: 9780896035911
ISBN: 0896035913
Untertitel: 'Contemporary Endocrinology'. 1999. Auflage. Sprache: Englisch.
Erscheinungsdatum: Januar 1999
Seitenanzahl: 392 Seiten
Format: gebunden
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