Combining Targeted Biological Agents with Radiotherapy: Current Status and Future Directions

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Juni 2008



This text is an overview of the current state of clinical and pre-clinical research in combining radiotherapy with targeted biological agents to fight cancer. The text provides a general overview of targeted agents, reviews the current clinical trials, and includes a look at the future of this state-of-the-art practice. This book begins with a general overview of the topic, including an introduction to the subject; the basic science rationale behind the two most important current targeted agents: epidermal growth factor (EGFR) receptors and vascular epithelial growth factor (VEGF) receptors; the dermatologic manifestations of targeted agents; and an introduction to radioimmunotherapy???a treatment that has the ability to combine targeted agents directly with radiotherapy. The second half of the book focuses on specific disease sites, including malignant gliomas, head and neck, lung, pancreatic, cervical, and endometrial cancers.


Targeted Therapies: Definitions, Limitations, and Future Directions; Epidermal Growth Factor (EGFR) Receptors; Vascular Epithelial Growth Factor (VEGF) Receptors; Dermatologic Manifestations of Targeted Therapies; Dermatologic Manifestations of Targeted Therapies; Radiolabelled Monoclonal Antibody Therapies; Targeted Therapies in Malignant Gliomas; Targeted Therapies in Head and Neck Cancer; Targeted Therapies in Lung Cancer; Targeted Therapies in Pancreatic Cancer; Targeted Therapies in Cervical Cancer; Targeted Therapies in Endometrial Cancer.


William Small, Jr., MD is Professor of Radiation Oncology and Vice-Chairman of the Department of Radiation Oncology at Northwestern University. He is the Associate Medical Director of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, and serves on the editorial board of the American Journal of Hematology/Oncology Review and Cancer News.
EAN: 9781933864341
ISBN: 1933864346
Untertitel: Sprache: Englisch.
Erscheinungsdatum: Juni 2008
Seitenanzahl: 226 Seiten
Format: gebunden
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