Chiral Separation Techniques

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Oktober 2006



Thoroughly revised, with either entirely new or completely updated contents, this is a practical manual for the small and large-scale preparation of enantiomerically pure products. The result is a vital resource for meeting the highest purity standards in the manufacture of chiral pharmaceuticals, food additives and related compounds. All the approaches covered here are highly relevant to modern manufacturing and quality control schemes in the pharmaceutical and biotech industries, addressing the increasingly important issue of drug safety in view of tougher regulatory standards worldwide.


1 Enantiomeric separations using macrocyclic glycopeptide stationary phases
2 The Role of Polysaccharides in Chiral Separations by Liquid Chromatography and Capillary Electrophoresis
3 Analytical and preparative potential of immobilized polysaccharide-derived chiral stationary phases
4 Chiral separations using supercritical fluid chromatography
5 Chiral ligand exchange in HPLC and CE
6 Advances in Simulated Moving Bed Chromatographic separations
7 Less common applications of enantioselective HPLC using the SMB technology in the pharmaceutical industry
8 Enatiomer Separation by Chiral Crown Ether Stationary phases
9 Chiral Separation of amino acids and hydroxy acids in HPLC with copper(II) complexes added to the eluent
10 Chiral Capillary Electrophoresis
11 Techniques in preparative chiral separations
12 Separation of enantiomers using molecularly imprinted polymers
13 Enantioselective Biosensors
14 Chiral analysis using CEC-UV and CEC-MS
15 Chiral analysis using MEKC-UV and MEKC-MS
16 Polarimeter Chiral Detectors in Enantioseparations
17 Preparative Chiral Chromatography - a powerful and efficient tool in drug discovery


With over 30 years experience in both industry and academia, Ganapathy Subramanian is a biotechnology consultant working in the application and development of processing, purification methodologies and chromatographic systems for large-scale use in environmental science, food science, perfumery cosmetics and pharmaceuticals. He has also taught extensively in the area of food and medical technology.
A chemistry graduate from Madras, India, he gained his doctorate from the University of Glasgow for work on natural products, and his main research interests lie in the utilization of natural material separation processes and bio-conversions.
Dr. Subramanian has written and edited a number of books and articles in the field of biotechnology. For the last 10 years, he has been organizing conferences promoting the integration and knowledge exchange between academia and industry.


From reviews of the first edition:
'Publication of this book is timely, and of immense value to the growth of this field'
Journal of Food Science

'A team of experts from academic and industrial laboratories throughout the world have compiled their findings and experience to make this book an exceptionally timely and unique contribution to the field'
European Journal of Drug Metabolism

'The dense mass of information contained in this book will make it a valuable resource ...'
Chemical Engineering Research

'... this is a worthwhile addition to the expanding chiral literature and the book should be of value to those working in this field'
The Analyst

'This book is a valuable reference and should find a readership among scientists in the field of pharmaceutical sciences.'

'...this book can be recommended to analysts confronted with chiral separations.'
Journal of Chromatography A

'In conclusion this is a useful volume written on the whole by workers in the field and deserving a place in the bench of doing chiral separations.'
Human and Experimental Technology

EAN: 9783527315093
ISBN: 3527315098
Untertitel: A Practical Approach. 3. vollständig überarbeitete und aktualisierte Auflage. Revised, Update. 200 Abbildungen, 60 Tabellen. Sprache: Englisch.
Verlag: Wiley VCH Verlag GmbH
Erscheinungsdatum: Oktober 2006
Seitenanzahl: XXII
Format: gebunden
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